The Killers' latest single release, "Tranquilize" features Lou Reed on guitar and he's provided his gravelly, speak-sing vocals to the track.

"Tranquilize" is off of 'Sawdust', a compilation of B-sides, rarities and remixes by the Las Vegas band. The collection is set for release on November 12, 2007 on CD in the UK (Nov. 13th in the US).

The video for "Tranquilize" was directed by Anthony Mandler ("When We Were Young"). The clip features Lou Reed, his face in the shadows alongside The Killers' Brandon Flowers. It's a dark, almost haunting video that complements the song's raw lyrics and lurid, emotional melodies.

Watch The Killers and Lou Reed video for "Tranquilize":

We also have a little behind the scenes action for you as well, with Matt Pinfield interviewing Lou Reed and Killers' frontman Brandon Flowers about the collaboration:

Watch the video interview here

"Tranquilize" single is available for download on iTunes and there's a limited edition etched "Tranquilize" vinyl 7".

Lou Reed Official Website

The Killers Official UK Website
The Killers on Myspace